Tolerance that occurs because the target tissue becomes less reactive to the drug after exposure is
A) situationally specific tolerance.
B) contingent tolerance.
C) reverse tolerance.
D) functional tolerance.
E) metabolic tolerance.

Question

Quizplus · Accepted Answer

Functional tolerance occurs when there is a decreased response to a drug due to physiological adaptation in the target tissue. This is also known as pharmacodynamic tolerance, as opposed to metabolic tolerance, which occurs due to changes in drug metabolism, or situational/conditional tolerance, which occurs due to environmental context or learned associations. Reverse tolerance, also known as sensitization, is the opposite of tolerance and results in an increased response to a drug over time. Contingent tolerance refers to a tolerance that develops only to certain effects or aspects of a drug's effects, rather than to the drug as a whole.

Tolerance That Occurs Because the Target Tissue Becomes Less Reactive