A granuloma is a more or less permanently walled-off structure within which nondestructible offending material is imprisoned.

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A granuloma is a type of chronic inflammation in which immune cells called macrophages form a core, called a tubercle, around offending material such as bacteria, fungi, or foreign bodies. This core is often surrounded by other immune cells, fibroblasts, and capillaries, creating a more or less permanent wall that isolates the offending material from the rest of the body. Granulomas can occur in various organs, such as the lungs, skin, or liver, and are a characteristic feature of many infectious, autoimmune, or allergic diseases.

A Granuloma Is a More or Less Permanently Walled-Off Structure