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Tubulysin D Is a Peptide-Based Marine Natural Product with Biological

Question 43

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Tubulysin D is a peptide-based marine natural product with biological activity.Identify the following structural features of tubulysin D.
(a) Place a box around any sp3 nitrogen.
(b) Star (*)any oxygen atom that has two oxygen lone pairs in sp2-hybridized orbitals.
(c) Place a number symbol (#)on any oxygen atom that is sp2 hybridized as a consequence of having a lone pair in a 2p orbital.
(d) Use an arrow to point to any N atom that has trigonal planar geometry. Tubulysin D is a peptide-based marine natural product with biological activity.Identify the following structural features of tubulysin D. (a) Place a box around any sp<sup>3</sup> nitrogen. (b) Star (*)any oxygen atom that has two oxygen lone pairs in sp<sup>2</sup>-hybridized orbitals. (c) Place a number symbol (#)on any oxygen atom that is sp<sup>2</sup> hybridized as a consequence of having a lone pair in a 2p orbital. (d) Use an arrow to point to any N atom that has trigonal planar geometry.

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