What is the initial step in the mechanism of fructose-1,6-bisphosphate aldolase when the substrate is fructose-1,6-bisphosphate in its open-chain form?

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Quizplus · Accepted Answer

The initial step in the mechanism of fructose-1,6-bisphosphate aldolase involves the attack of the C-2 carbonyl group by the amine of lysine. This forms a Schiff base intermediate, facilitating the subsequent steps in the cleavage of fructose-1,6-bisphosphate into two three-carbon molecules.

What Is the Initial Step in the Mechanism of Fructose-1,6-Bisphosphate