Which of the following enzymes of the pyruvate dehydrogenase complex is responsible for the oxidation of the hydroxyethyl group from pyruvate decarboxylation to an acetyl group?
A)pyruvate dehydrogenase
B)dihydrolipoamide transacetylase
C)dihydrolipoamide dehydrogenase
D)pyruvate dehydrogenase kinase
E)pyruvate dehydrogenase phosphatase

Question

Quizplus · Accepted Answer

Dihydrolipoamide transacetylase is responsible for the transfer of the hydroxyethyl group to coenzyme A, which results in the formation of an acetyl group. Pyruvate dehydrogenase catalyzes the decarboxylation of pyruvate to form the hydroxyethyl group. Dihydrolipoamide dehydrogenase regenerates the oxidized lipoamide cofactor required for the function of dihydrolipoamide transacetylase. Pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase regulate the activity of the pyruvate dehydrogenase complex.

Which of the Following Enzymes of the Pyruvate Dehydrogenase Complex