Which of the following classes of proteins associates with the membrane bilayer with the lowest energy and would therefore be most difficult to separate from the membrane?
A)extrinsic proteins
B)lipid-linked proteins
C)transmembrane proteins
D)peripheral proteins
E)hydrophilic proteins

Question

Quizplus · Accepted Answer

Transmembrane proteins are embedded within the hydrophobic regions of the lipid bilayer making it difficult to separate them from the membrane. They have the lowest free energy of association with the membrane among the given classes of proteins. Extrinsic and peripheral proteins are loosely bound to the membrane and can be easily separated, while lipid-linked proteins are attached to the membrane through lipid anchors, which can be cleaved enzymatically. Hydrophilic proteins would have the highest energy of association with the hydrophobic membrane bilayer and would be unable to stably associate with the membrane.

Which of the Following Classes of Proteins Associates with the Membrane