Which of the following segments of the integral membrane protein glycophorin most likely contains the membrane-spanning sequence?
A)LSTTEVAMHTTTSSSVSKSY
B)SQTNDTHKRDTYAATPRA
C)VSEISVRTVYPPEEETGE
D)ITLIIFGVMAGVIGTILLI
E)YGIRRLIKKSPSDVKPLP

Question

Quizplus · Accepted Answer

The membrane-spanning sequence is typically composed of hydrophobic amino acids, which help anchor the protein within the lipid bilayer of the membrane. Choice D contains a series of hydrophobic amino acids (Isoleucine, Phenylalanine, Valine, Methionine, Alanine, Glycine, Valine, Isoleucine, Glycine, Threonine, Isoleucine, Leucine, Leucine, and Isoleucine), suggesting that this segment is most likely the membrane-spanning region.

Which of the Following Segments of the Integral Membrane Protein