Consider the Schiff base formation reaction discussed in the catalytic mechanisms section of the chapter.What would probably happen if the carboxylate group was stabilized by a nearby positive charge?
A)The Schiff base would donate a lone pair of electrons to the substrate.
B)The Schiff base would form prior to decarboxylation.
C)The reaction would proceed with nucleophilic attack on the enzyme by the electrophilic substrate.
D)All of the above would be possible given the discussed mechanism with a stabilized carboxyl group.
E)None of the above is plausible considering the discussed mechanism with a stabilized carboxylate group.

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The Answer of Consider the Schiff base formation reaction discussed in the catalytic mechanisms section of the chapter.What would probably happen if the carboxylate group was stabilized by a nearby positive charge?
A)The Schiff base would donate a lone pair of electrons to the substrate.
B)The Schiff base would form prior to decarboxylation.
C)The reaction would proceed with nucleophilic attack on the enzyme by the electrophilic substrate.
D)All of the above would be possible given the discussed mechanism with a stabilized carboxyl group.
E)None of the above is plausible considering the discussed mechanism with a stabilized carboxylate group.

Consider the Schiff Base Formation Reaction Discussed in the Catalytic