Which of the following is(are)TRUE concerning the metabolic reaction shown below? Pyruvate + NAD⁺ + CoA-SH SYMBOL 174 \f "Symbol" Acetyl-CoA + NADH + H⁺ + CO₂ (I)The enzyme that catalyzes this reaction contains a pyridoxal phosphate prosthetic group. (II)This reaction is an oxidative decarboxylation. (III)The enzyme that catalyzes this metabolic conversion is activated by high concentrations of ATP. A)I,II,III B)II,III C)II only D)III only E)I,II

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This reaction is an example of oxidative decarboxylation, where pyruvate is converted into acetyl-CoA, NADH, and CO2. The enzyme catalyzing this reaction does not use a pyridoxal phosphate prosthetic group; instead, it involves a lipoamide arm for the transfer of the acetyl group. Additionally, the enzyme (pyruvate dehydrogenase complex) is inhibited, not activated, by high concentrations of ATP, indicating that options I and III are incorrect.

Which of the Following Is(are)TRUE Concerning the Metabolic Reaction Shown