Which of the following causes pyruvate dehydrogenase kinase to catalyze the phosphorylation and inactivation of E₁ in the pyruvate dehydrogenase complex? A)elevated concentrations of NADH and ATP B)elevated concentrations of NAD⁺ and ADP C)insulin D)elevated concentrations of acetyl-CoA E)C and D

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Quizplus · Accepted Answer

Elevated concentrations of NADH and ATP are signals that there is an abundance of energy in the cell, so it makes sense to inhibit the pyruvate dehydrogenase complex and prevent the production of more acetyl-CoA. Pyruvate dehydrogenase kinase is activated by high levels of ATP and NADH, and it phosphorylates and inactivates the complex.

Which of the Following Causes Pyruvate Dehydrogenase Kinase to Catalyze