An individual with a shortage of B vitamins (which include thiamine and riboflavin)may feel fatigued as a result of decreased pyruvate dehydrogenase activity.Which of the following would be TRUE regarding this shortage?
A)The amount of acetyl CoA produced from carbohydrate metabolism that enters the citric acid cycle would be decreased.
B)A decrease in the amount of NADH would likely decrease activity of citrate synthase.
C)Flux through the citric acid cycle would cease until adequate pyruvate is available.
D)none of the above
E)all of the above

Question

Quizplus · Accepted Answer

Thiamine and riboflavin are essential for the activity of pyruvate dehydrogenase, an enzyme that converts pyruvate to acetyl CoA, which enters the citric acid cycle. Without adequate B vitamins, pyruvate dehydrogenase activity decreases, leading to a decreased amount of acetyl CoA produced from carbohydrate metabolism that enters the citric acid cycle.

B and C are incorrect as there is no direct relationship between B vitamin deficiency and the activity of citrate synthase or the cessation of flux through the citric acid cycle.

An Individual with a Shortage of B Vitamins (Which Include