Individuals with an Alanine to Valine Mutation in N⁵,N¹⁰ -

Individuals with an alanine to valine mutation in N⁵,N¹⁰ - methylenetetrahydrofolate reductase (MTHFR)
(I) typically have higher levels of homocysteine.
(II) have increased risk for cardiovascular disease.
(III) typically have increased incidence of oxidative damage to the walls of blood vessels.
(IV) are at increased risk,if female,of giving birth to a child with a neural tube defect.

A) I,II
B) II,III
C) I only
D) IV only
E) I,II,III,IV