A mutation in GDH of patients with HI/HA (hypoglycemia/hyperammonemia)results in a decrease in allosteric control of GDH via GTP.Which of the following will be observed in the patients?

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The mutation in GDH (glutamate dehydrogenase) that decreases its allosteric control by GTP in patients with hypoglycemia/hyperammonemia (HI/HA) syndrome leads to increased GDH activity. This results in more glutamate being converted into alpha-ketoglutarate and ammonia, thereby increasing levels of ammonia. The reaction also involves the conversion of NAD+ to NADH, thus increasing NADH levels. Therefore, both an increase in ammonia and an increase in NADH will be observed.

A Mutation in GDH of Patients with HI/HA (Hypoglycemia/hyperammonemia)results in a Decrease