Imagine that a new drug is proposed which is hypothesized to selectively bind the transcription factor TBP.Which of the following would be affected?
(I)RNA polymerase I
(II)RNA polymerase II
(III)RNA polymerase III
(IV)E.coli RNA polymerase
A)I,II,III,IV
B)I,II,III
C)I only
D)II only
E)IV only

Question

Quizplus · Accepted Answer

TBP (TATA-binding protein) is a component of the transcription factor complex TFIID, which is involved in the initiation of transcription by RNA polymerase II in eukaryotes. It also plays roles in the transcription initiation of RNA polymerase I and III. E.coli RNA polymerase would not be affected as it is a prokaryotic enzyme and does not utilize TBP for transcription initiation.

Imagine That a New Drug Is Proposed Which Is Hypothesized