How Is a Sequence Different from a Syndrome

How is a sequence different from a syndrome?

A) A sequence is usually caused by a single gene mutation,and a syndrome is always caused by a chromosomal abnormality.
B) A syndrome is usually caused by a single gene mutation,and a sequence is always caused by a chromosomal abnormality.
C) In a syndrome one structural problem leads to development of other problems,whereas a sequence is a collection of separate but consistent anomalies.
D) In a sequence one structural problem leads to development of other problems,whereas a syndrome is a collection of separate but consistent anomalies.