How does histone modification alter gene expression?

Question

Quizplus · Accepted Answer

Histone modification can result in alteration of chromatin structure, making the DNA more or less accessible to transcription factors and enzymes required for transcription. In areas where histones are modified, such as through methylation or acetylation, the DNA is more tightly wound around the histones and genes may not be transcribed. Therefore, histone modification can alter gene expression by regulating accessibility of the DNA to transcriptional machinery.

How Does Histone Modification Alter Gene Expression