The mutation that would lead to the most dramatic effect on Ca²⁺ transport is a mutation of A) Ser16 in phospholamban. B) Thr17 in phospholamban. C) Asp351 in SERCA. D) Ser17 in E2P.

Question

Quizplus · Accepted Answer

Asp351 is a critical residue in the ATP binding site of SERCA, and mutation of this residue would likely have the most dramatic effect on the Ca²⁺ transport as it would impair ATP hydrolysis and consequently reduce the activity of SERCA. Mutations in Ser16 or Thr17 in phospholamban may affect its ability to regulate SERCA activity, but these mutations would have a more limited effect on Ca²⁺ transport. Ser17 in E2P is not directly involved in Ca²⁺ transport and likely would not have a significant effect on this process.

The Mutation That Would Lead to the Most Dramatic Effect