Which of the following may result from a His143 Ala143 mutation in adult hemoglobin? A) decreased CO₂ transport efficiency B) increased oxygen transport efficiency C) reduced affinity for 2,3-BPG D) sickle cell anemia

Question

Quizplus · Accepted Answer

His143 is located in the beta chain of adult hemoglobin, and its mutation to Ala143 results in a decreased affinity for 2,3-BPG, which reduces the ability of hemoglobin to release oxygen to tissues. This may result in a condition such as hypoxia or cyanosis, but not sickle cell anemia, which is caused by a different mutation in the beta chain of hemoglobin. The other options are not directly related to the function of hemoglobin and are therefore unlikely consequences of this mutation.

Which of the Following May Result from a His143