Question 1

Approximately how many amino acids are identical in both myoglobin and the adult  -subunit of hemoglobin?

Accepted Answer

The answer of Approximately how many amino acids are identical...

Question 2

The  subunit of adult hemoglobin has higher sequence similarity to __________ than to __________.

Accepted Answer

The answer of The  subunit of adult hemoglobin has...

Question 3

A molecule is found to be able to diffuse across a membrane.Which of the following characteristics would best describe this molecule?

Accepted Answer

The answer of A molecule is found to be able...

Question 4

Consider the following interaction between a protein and its ligand: [P] + [L]  [PL].If [L] = 5 mM,[P] = 3 mM,and [PL] = 2 mM,what is the dissociation constant?

Accepted Answer

The answer of Consider the following interaction between a protein...

Question 5

Look at the data in the figure below.If the sequence for the  subunit was replaced with the 
Subunit sequence from a patient with sickle cell disease,the number of

Accepted Answer

The answer of Look at the data in the figure...

Question 6

Consider an allosteric protein that contains three identical subunits.Which of the following is true only if the protein follows the concerted model of allostery and NOT the sequential model of allostery?

Accepted Answer

The answer of Consider an allosteric protein that contains three...

Question 7

Which of the following is NOT a symptom of anemia?

Accepted Answer

Excessive bleeding is not a symptom of anemia. Anemia is typically characterized by fatigue, shortness of breath, and cognitive decline due to a deficiency in red blood cells or hemoglobin. Excessive bleeding may lead to anemia, but it is not a symptom of anemia itself.

Question 8

A protein that follows the concerted model of allosteric regulation would display a binding curve that is __________.A protein that follows the sequential model of allosteric regulation would display a binding curve that is __________.

Accepted Answer

The answer of A protein that follows the concerted model...

Question 9

The translocation rate of a solute across a membrane is measured.A plot of translocation rate versus solute concentration displays a hyperbolic curve.The translation

Accepted Answer

A hyperbolic curve suggests that the translocation is saturable, meaning there is a limit to the rate of transport based on the availability of a particular transport protein. This indicates that the solute is likely transported via a carrier protein rather than through passive diffusion. Since the transport is passive, no input of energy is required, making option A incorrect. Option B is also incorrect since diffusion does not involve the use of carrier proteins. Thus, option C is the best choice as it correctly describes the transport mechanism.

Question 10

Using the oxygen binding curve shown,calculate the approximate percentage of O₂ that is released from hemoglobin as the pO₂ changes from 13 kPa to 4 kPa.

Accepted Answer

The answer of Using the oxygen binding curve shown,calculate the...

Question 11

A mutation of the N-terminal valine in adult hemoglobin occurs.The amino acid is replaced with an isoleucine.Studies show that the replacement does not alter the overall structure of the protein.Which of the following hemoglobin functions may be altered?

Accepted Answer

The answer of A mutation of the N-terminal valine in...

Question 12

What type of transport is depicted in the figure below?

Accepted Answer

The figure depicts molecules moving from an area of high concentration to an area of low concentration, which is characteristic of passive transport. The direction of transport is down the concentration gradient, meaning the molecules are not being moved by an external force or energy source, but rather are moving spontaneously to reach equilibrium.

Question 13

The fractional saturation of hemoglobin (Hb)binding to oxygen is illustrated by

Accepted Answer

The fractional saturation of hemoglobin is the ratio of oxyhemoglobin concentration to the total hemoglobin concentration, which is the sum of oxyhemoglobin and deoxyhemoglobin.

Question 14

The estrogen receptor is an example of a

Accepted Answer

The estrogen receptor is a cell signaling protein that binds to estrogen, a hormone that is involved in the regulation of several physiological processes. Once bound to estrogen, the receptor undergoes a conformational change that allows it to bind to DNA and regulate the expression of target genes. This makes it an important player in the genomic response to estrogen, and thus implicated in various hormonal diseases including breast cancer.

Question 15

Which of the following pairs are paralogous genes?

Accepted Answer

The answer of Which of the following pairs are paralogous...

Question 16

Which of the following groups are hydrogen bonded in oxyhemoglobin but not deoxyhemoglobin?

Accepted Answer

In oxyhemoglobin, the hydrogen bond between Asp94 and Asn102 is formed due to the conformational change upon oxygen binding, which is not present in deoxyhemoglobin.

Question 17

Oxygen binding is monitored for a solution of hemoglobin.During the experiment,the curve changes from sigmoidal to hyperbolic.Which of the following may be the reason for the change?

Accepted Answer

The sigmoidal curve of hemoglobin is due to cooperative binding among its subunits. If the protein dissociates into individual subunits, it loses this cooperativity, resulting in a hyperbolic curve similar to that of myoglobin.

Question 18

Which of the following may result from a His143  Ala143 mutation in adult hemoglobin?

Accepted Answer

His143 is located in the beta chain of adult hemoglobin, and its mutation to Ala143 results in a decreased affinity for 2,3-BPG, which reduces the ability of hemoglobin to release oxygen to tissues. This may result in a condition such as hypoxia or cyanosis, but not sickle cell anemia, which is caused by a different mutation in the beta chain of hemoglobin. The other options are not directly related to the function of hemoglobin and are therefore unlikely consequences of this mutation.

Question 19

Which of the following curves is representative of the binding of oxygen to myoglobin?

Accepted Answer

Curve A represents the typical binding curve for myoglobin, which has a high affinity for oxygen, meaning that it can bind oxygen readily at very low partial pressures. This curve is steep at low partial pressures and plateaus at higher partial pressures, indicating that almost all the oxygen is bound to myoglobin at these concentrations. Curves B, C, and D are not representative of myoglobin's binding curve as they either have a lower affinity or exhibit cooperative binding tendencies.

Question 20

Which of the following is true of sickle cell anemia?

Accepted Answer

The answer of Which of the following is true of...

Quiz 6: Protein Function

Approximately how many amino acids are identical in both myoglobin and the adult -subunit of hemoglobin?

The subunit of adult hemoglobin has higher sequence similarity to than to .

A molecule is found to be able to diffuse across a membrane.Which of the following characteristics would best describe this molecule?

Consider the following interaction between a protein and its ligand: [P] + [L] [PL].If [L] = 5 mM,[P] = 3 mM,and [PL] = 2 mM,what is the dissociation constant?

Look at the data in the figure below.If the sequence for the subunit was replaced with the Subunit sequence from a patient with sickle cell disease,the number of

Consider an allosteric protein that contains three identical subunits.Which of the following is true only if the protein follows the concerted model of allostery and NOT the sequential model of allostery?

Which of the following is NOT a symptom of anemia?

A protein that follows the concerted model of allosteric regulation would display a binding curve that is .A protein that follows the sequential model of allosteric regulation would display a binding curve that is .

The translocation rate of a solute across a membrane is measured.A plot of translocation rate versus solute concentration displays a hyperbolic curve.The translation

Using the oxygen binding curve shown,calculate the approximate percentage of O₂ that is released from hemoglobin as the pO₂ changes from 13 kPa to 4 kPa.

A mutation of the N-terminal valine in adult hemoglobin occurs.The amino acid is replaced with an isoleucine.Studies show that the replacement does not alter the overall structure of the protein.Which of the following hemoglobin functions may be altered?

What type of transport is depicted in the figure below?

The fractional saturation of hemoglobin (Hb) binding to oxygen is illustrated by

The estrogen receptor is an example of a

Which of the following pairs are paralogous genes?

Which of the following groups are hydrogen bonded in oxyhemoglobin but not deoxyhemoglobin?

Oxygen binding is monitored for a solution of hemoglobin.During the experiment,the curve changes from sigmoidal to hyperbolic.Which of the following may be the reason for the change?

Which of the following may result from a His143 Ala143 mutation in adult hemoglobin?

Which of the following curves is representative of the binding of oxygen to myoglobin?

Which of the following is true of sickle cell anemia?

Quiz 6: Protein Function

Approximately how many amino acids are identical in both myoglobin and the adult -subunit of hemoglobin?

The subunit of adult hemoglobin has higher sequence similarity to __________ than to __________.

A molecule is found to be able to diffuse across a membrane.Which of the following characteristics would best describe this molecule?

Consider the following interaction between a protein and its ligand: [P] + [L] [PL].If [L] = 5 mM,[P] = 3 mM,and [PL] = 2 mM,what is the dissociation constant?

Look at the data in the figure below.If the sequence for the subunit was replaced with the Subunit sequence from a patient with sickle cell disease,the number of

Consider an allosteric protein that contains three identical subunits.Which of the following is true only if the protein follows the concerted model of allostery and NOT the sequential model of allostery?

Which of the following is NOT a symptom of anemia?

A protein that follows the concerted model of allosteric regulation would display a binding curve that is __________.A protein that follows the sequential model of allosteric regulation would display a binding curve that is __________.

The translocation rate of a solute across a membrane is measured.A plot of translocation rate versus solute concentration displays a hyperbolic curve.The translation

Using the oxygen binding curve shown,calculate the approximate percentage of O2 that is released from hemoglobin as the pO2 changes from 13 kPa to 4 kPa.

A mutation of the N-terminal valine in adult hemoglobin occurs.The amino acid is replaced with an isoleucine.Studies show that the replacement does not alter the overall structure of the protein.Which of the following hemoglobin functions may be altered?

What type of transport is depicted in the figure below?

The fractional saturation of hemoglobin (Hb) binding to oxygen is illustrated by

The estrogen receptor is an example of a

Which of the following pairs are paralogous genes?

Which of the following groups are hydrogen bonded in oxyhemoglobin but not deoxyhemoglobin?

Oxygen binding is monitored for a solution of hemoglobin.During the experiment,the curve changes from sigmoidal to hyperbolic.Which of the following may be the reason for the change?

Which of the following may result from a His143 Ala143 mutation in adult hemoglobin?

Which of the following curves is representative of the binding of oxygen to myoglobin?

Which of the following is true of sickle cell anemia?

The subunit of adult hemoglobin has higher sequence similarity to than to .

A protein that follows the concerted model of allosteric regulation would display a binding curve that is .A protein that follows the sequential model of allosteric regulation would display a binding curve that is .

Using the oxygen binding curve shown,calculate the approximate percentage of O₂ that is released from hemoglobin as the pO₂ changes from 13 kPa to 4 kPa.