A mutation in the subunit of hemoglobin is discovered that reduces the affinity of 2,3-BPG binding.Which of the following mutations is most likely to have this consequence?
A) Val1
B) Asp99 Glu99
C) Lys82 Asp82
D) Glu6 Val6

Question

A mutation in the  subunit of hemoglobin is discovered that reduces the affinity of 2,3-BPG binding.Which of the following mutations is most likely to have this consequence?
A) Val1 
B) Asp99 Glu99 
C) Lys82 Asp82 
D) Glu6 Val6

Quizplus · Accepted Answer

Lysine (K) at position 82 of the β-subunit of hemoglobin interacts with 2,3-BPG, and a mutation to aspartic acid (D) at this position has been found to reduce its binding. Thus, a mutation from Lysine to another amino acid which disrupts this interaction would decrease 2,3-BPG binding affinity. Asp99, Glu6, and Val1 are not close to the 2,3-BPG binding site, and mutation to Ileine, Valine, and Glutamic acid respectively is unlikely to affect 2,3-BPG binding.

A Mutation in the Subunit of Hemoglobin Is Discovered