When a nucleophile present in the enzyme attacks an electrophilic substrate to form an enzyme-substrate intermediate,this is an example of __________ catalysis.
A) covalent
B) acid-base
C) metal ion
D) hydrophobic

Question

Quizplus · Accepted Answer

In covalent catalysis, the enzyme forms a covalent bond with the substrate, typically bringing the reactive groups of both molecules into closer proximity and reducing the activation energy required for the reaction to occur. The formation of an enzyme-substrate intermediate through nucleophilic attack is a classic example of covalent catalysis. Acid-base and metal ion catalysis involve the transfer of protons or other charged particles, while hydrophobic catalysis involves the formation of nonpolar interactions between the enzyme and substrate.

When a Nucleophile Present in the Enzyme Attacks an Electrophilic