If protein kinase A is activated in a liver cell in response to glucagon binding to the 2-adrenergic receptor,which of the following will result?
A) Glycogen synthesis will be turned on.
B) Glycogen degradation will be turned on.
C) Glucose synthesis will be turned off.
D) GLUT1 expression will be upregulated.

Question

If protein kinase A is activated in a liver cell in response to glucagon binding to the  2-adrenergic receptor,which of the following will result?
A) Glycogen synthesis will be turned on. 
B) Glycogen degradation will be turned on. 
C) Glucose synthesis will be turned off. 
D) GLUT1 expression will be upregulated.

Quizplus · Accepted Answer

Protein kinase A activation in response to glucagon binding to the β2-adrenergic receptor in liver cells leads to the activation of glycogen phosphorylase and the inhibition of glycogen synthase, resulting in glycogen degradation. Therefore, choice B is the correct answer. Choices A, C, and D are not correct because they suggest effects that are opposite to what actually happens in response to protein kinase A activation by glucagon.

If Protein Kinase a Is Activated in a Liver Cell