Which scenario would allow -arrestin to bind to the GPCR?
A) ARK is internalized into the endosome.
B) The receptor is phosphorylated.
C) is bound to GDP.
D) The regulatory subunit of -arrestin is removed.

Question

Which scenario would allow  -arrestin to bind to the GPCR?
A) ARK is internalized into the endosome. 
B) The receptor is phosphorylated. 
C) is bound to GDP. 
D) The regulatory subunit of -arrestin is removed.

Quizplus · Accepted Answer

Arrestin binding to a GPCR usually occurs after the receptor has been phosphorylated by a specific kinase. This phosphorylation serves as a signal for β-arrestin to bind to the receptor, which subsequently leads to desensitization and internalization of the receptor. Therefore, choice B is the correct answer as it describes a scenario where the receptor is phosphorylated.

Which Scenario Would Allow -Arrestin to Bind to the GPCR