Which enzyme is the main regulator of glycolysis?

Question

Quizplus · Accepted Answer

PFK-1 (phosphofructokinase-1) is the main regulatory enzyme of glycolysis. It catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate, which is a committed step in glycolysis. PFK-1 is activated by high energy states (low ATP/ADP ratio) and inhibited by low energy states (high ATP/ADP ratio). This allows for the control of glycolysis in response to the energy needs of the cell. While the other enzymes listed (hexokinase, pyruvate kinase, and aldolase) are also important in glycolysis, they do not have the same level of regulatory control as PFK-1.

Which Enzyme Is the Main Regulator of Glycolysis