How is the pyruvate dehydrogenase reaction regulated?
A) pH and enzyme conformation
B) pH and the protonation state of the active site
C) allosteric control and covalent modification
D) product inhibition

Question

Quizplus · Accepted Answer

The pyruvate dehydrogenase reaction is regulated by both allosteric control and covalent modification. Allosteric control involves the binding of regulatory molecules to non-active site locations on enzymes, which can activate or inhibit enzyme activity. Covalent modification involves the addition or removal of chemical groups to the enzyme protein, which can also activate or inhibit enzyme activity.

How Is the Pyruvate Dehydrogenase Reaction Regulated