DNA polymerase does not make mismatched base pairs because
A) there are no hydrogen bonds that line up between the mismatches.
B) the active site does not fit mismatches well.
C) the mismatched pairs make covalent bonds instead of hydrogen bonds.
D) the DNA primer does not allow for mismatched pairs.

Question

Quizplus · Accepted Answer

DNA polymerase has an active site that specifically fits complementary base pairs. Mismatched base pairs will not fit well into the active site and therefore, DNA polymerase cannot add them to the growing strand.

DNA Polymerase Does Not Make Mismatched Base Pairs Because