If a strand of DNA has a large lesion that distorts the helical nature of the DNA,what would be the mechanism of repair?
A) mismatch repair
B) abasic repair
C) base excision
D) nucleotide excision

Question

Quizplus · Accepted Answer

A distorted strand of DNA would require nucleotide excision repair, which involves cutting and replacing a segment of damaged DNA. This mechanism is able to repair damage such as bulky lesions that cause distortions in the helical structure of DNA. Mismatch repair and base excision repair are more suited for smaller lesions that involve incorrect base pairings or damaged individual bases. Abasic repair is specific for repairing sites that lack a base altogether.

If a Strand of DNA Has a Large Lesion That