Homologous recombination can only be used in late S phase or G2 phase because it
A) requires the presence of an intact sister chromatid as a template.
B) does not require the presence of a homologous template.
C) requires the cell to be in cell division.
D) requires the cell to be in the resting phase.

Question

Quizplus · Accepted Answer

Homologous recombination requires an intact sister chromatid as a template for repair. This means that it can only occur after DNA replication in late S phase or G2 phase when sister chromatids are present. Option B is incorrect because homologous recombination does require a homologous template. Option C is incorrect because cell division is not a requirement for homologous recombination. Option D is incorrect because the resting phase does not provide the necessary conditions for homologous recombination.

Homologous Recombination Can Only Be Used in Late S Phase