Binding of a lectin to a sugar found in bacteria and fungi occurs in which complement pathway?

Question

Quizplus · Accepted Answer

The MBL pathway is activated when mannose-binding lectin (MBL) binds to carbohydrates on bacterial and fungal surfaces. This binding activates MBL-associated serine proteases, which cleave complement component C4 and C2. The resulting complex, C4bC2a, acts as C3 convertase and activates the classical pathway to generate the terminal complement complex. Therefore, a lectin binding to a sugar found in bacteria and fungi specifically activates the MBL pathway.

Binding of a Lectin to a Sugar Found in Bacteria