What is given to patients who have crossed over to an Rh-positive blood type via massive transfusion to prevent anti-D formation?

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RhIG (anti-D immunoglobulin) is given to prevent the formation of antibodies against the Rh factor (D antigen) in Rh-negative patients who have been exposed to Rh-positive blood via massive transfusion. This can occur because small amounts of Rh-positive blood can enter the circulation and stimulate antibody production. RhIG binds to and removes any Rh-positive cells before the patient's immune system can react and produce antibodies, thereby preventing sensitization. Cryoprecipitate (A) is a blood component used to treat bleeding disorders, Factor VIII concentrate (D) is a treatment for hemophilia A, and enzyme-treated cells (C) may be used to treat individuals with certain red blood cell enzyme deficiencies, but none of these are used to prevent anti-D formation in Rh-negative patients.

What Is Given to Patients Who Have Crossed Over to an Rh-Positive