Interphase FISH has been performed on a patient sample. With a chromosome 8 centromeric (CEP 8) probe, two signals are observed in each spread examined. A probe for the immunoglobulin heavy chain region on chromosome 14 gives two distinct signals per nucleus, and a probe for the myc gene on chromosome 8 gives two distinct signals per nucleus. Which of following interpretations is correct?

Question

Quizplus · Accepted Answer

The presence of two signals for each probe suggests no loss or gain of chromosomal material, and the absence of any aberrant signal patterns rules out the possibilities of translocations or insertions. Therefore, this is a normal result.

Interphase FISH Has Been Performed on a Patient Sample