In the platelet neutralization procedure for lupus anticoagulants (LAs), after mixing LA plasma with freeze-thawed platelet lysate, the __________ will be shortened.

Question

Quizplus · Accepted Answer

The APTT, or activated partial thromboplastin time, measures the intrinsic pathway of the coagulation cascade and is commonly used to screen for LAs. In the platelet neutralization procedure, LAs will bind to phospholipids on the platelet membrane and interfere with clotting, resulting in an abnormally prolonged APTT. Adding freeze-thawed platelet lysate to the LA plasma will neutralize the LAs and correct the clotting time, shortening the APTT. Therefore, the correct answer is B.

In the Platelet Neutralization Procedure for Lupus Anticoagulants (LAs), After