In patients with alcoholic cirrhosis, thrombocytopenia and platelet abnormalities may result from the direct toxic effect of alcohol on bone marrow __________, leading to an ineffective thrombopoiesis.

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Megakaryocytes are the precursor cells that give rise to platelets (thrombopoiesis). Alcohol toxic effects on bone marrow can lead to ineffective thrombopoiesis resulting in thrombocytopenia and platelet abnormalities in patients with alcoholic cirrhosis.

In Patients with Alcoholic Cirrhosis, Thrombocytopenia and Platelet Abnormalities May