Serum protein electrophoresis (SPEP) demonstrates the absence of a gamma peak. This finding is consistent with which plasma cell disorder?

Question

Quizplus · Accepted Answer

The gamma peak on serum protein electrophoresis represents the gamma globulin fraction, which is composed predominantly of immunoglobulins. The absence of a gamma peak suggests a low level of immunoglobulins, which is consistent with hypogammaglobulinemia. IgG myeloma with M-spike would show an elevated gamma peak, hypergammaglobulinemia shows an increase in gamma peak, and Waldenström's macroglobulinemia shows an increase in the gamma globulin fraction with a monoclonal spike in the IgM region.

Serum Protein Electrophoresis (SPEP) Demonstrates the Absence of a Gamma