What is the cause of decreased production of formed elements in the marrow (red cells, white cells, platelets) seen in patients with multiple myeloma?

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Multiple myeloma is a malignancy of plasma cells that leads to the replacement of normal bone marrow tissue with a malignant plasma cell mass. This results in a decrease in the production of all types of formed elements in the marrow, including red cells, white cells, and platelets. Stem cell defects and growth factor deficiencies may also play a role in the pathogenesis of multiple myeloma, but they are not the primary cause of the decreased production of formed elements.

What Is the Cause of Decreased Production of Formed Elements