Which monoclonal gammopathy occurs in the sixth to eighth decade of life and is characterized by the presence of an M-spike with IgG

Question

Which monoclonal gammopathy occurs in the sixth to eighth decade of life and is characterized by the presence of an M-spike with IgG < 3.5 g/dL, IgA < 20 g/dL, urinary light chains < 1.0 g/24 hr, and < 10% plasma cells in the bone marrow?

Quizplus · Accepted Answer

The description matches with the diagnostic criteria of monoclonal gammopathy of undetermined significance (MGUS), which is a common asymptomatic disorder observed in the elderly population. Other monoclonal gammopathies such as multiple myeloma, Waldenström's macroglobulinemia, and solitary plasmacytoma have different clinical and laboratory presentations.

Which Monoclonal Gammopathy Occurs in the Sixth to Eighth Decade