Which of the following classic hematologic features of sickle cell anemia can be observed on the peripheral blood smear?

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All of the classic hematologic features of sickle cell anemia can be observed on the peripheral blood smear, including target cells, nucleated red cells, sickle cells, and anisocytosis and poikilocytosis. Target cells are caused by the excess membrane produced as a result of sickling, while the presence of nucleated red cells reflects the bone marrow response to the chronic anemia. Sickle cells, which result from the abnormal hemoglobin in sickle cell anemia, give the disease its name, and anisocytosis and poikilocytosis refer to the various abnormalities in size and shape that are seen in red blood cells in the disease.

Which of the Following Classic Hematologic Features of Sickle Cell