Which of the following clinical features is characteristic of sickle cell anemia?

Question

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All of the listed clinical features can be characteristic of sickle cell anemia. Severe anemia results from the destruction of sickled red blood cells, cardiac enlargement can occur due to chronic anemia leading to increased cardiac workload, icterus (jaundice) is a result of the breakdown of red blood cells, and leukocytosis can occur as part of the body's response to the chronic inflammation and infection risk associated with sickle cell disease.

Which of the Following Clinical Features Is Characteristic of Sickle