The diagnosis of G6PD deficiency in a black man during acute hemolysis may be difficult to detect in a screening test due to:

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During acute hemolysis, the increased number of younger red cells (reticulocytes) that have normal levels of G6PD and a lack of older G6PD-deficient red cells due to hemolysis can make it difficult to detect G6PD deficiency in a screening test. This is because screening tests rely on the detection of G6PD-deficient red cells, and during acute hemolysis these may not be present or may be present in very low numbers. Drug interference, the presence of too many G6PD-deficient red cells, or the presence of white blood cells or platelets are not likely to affect the screening test for G6PD deficiency.

The Diagnosis of G6PD Deficiency in a Black Man During