Which of the following characterizes hereditary spherocytosis (HS)?

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All of the choices are characteristic features of hereditary spherocytosis (HS). HS is an inherited disorder characterized by defects in one or more of the proteins involved in the structure and function of the red blood cell membrane. These defects lead to a decrease in the surface-to-volume ratio of the red blood cells, resulting in their spherical shape. Due to their abnormal shape, spherocytes are easily destroyed, leading to hemolytic anemia. The destruction of red blood cells also leads to an increased mean corpuscular hemoglobin concentration (MCHC) on blood tests.

Which of the Following Characterizes Hereditary Spherocytosis (HS)