Schistocytes or fragmented red cells seen on a peripheral blood smear of a PNH patient may indicate:

Question

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Schistocytes or fragmented red cells are often a sign of intravascular hemolysis, which can be caused by red blood cells being destroyed as they pass through small blood vessels that have been obstructed by thrombi. Therefore, the presence of schistocytes on a peripheral blood smear of a PNH patient may indicate intravascular thrombosis.

Schistocytes or Fragmented Red Cells Seen on a Peripheral Blood