The presentation of hemoglobinuria in a PNH patient is due to:

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Quizplus · Accepted Answer

Hemoglobinuria in PNH is primarily due to intravascular hemolysis, where red blood cells are lysed within the blood vessels, leading to the release of free hemoglobin into the plasma, which is then filtered by the kidneys and excreted in the urine. Extravascular hemolysis, on the other hand, occurs mainly in the spleen and liver and does not result in the release of free hemoglobin into the circulation. Biphasic hemolysis is a term used to describe the combination of both intravascular and extravascular hemolysis, but it is not relevant to the presentation of hemoglobinuria in PNH. Immune hemolysis is a different mechanism that involves the destruction of red blood cells by the immune system, which is not the primary cause of hemoglobinuria in PNH.

The Presentation of Hemoglobinuria in a PNH Patient Is Due