What factor affects the red cell's tendency to sickle in sickle cell anemia?

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Sickle cell anemia is caused by a mutation in the HBB gene that results in the production of abnormal hemoglobin (HbS). The abnormal HbS has a tendency to stick together and form rigid, sickle-shaped red blood cells. This tendency is influenced by the oxygen tension in the blood. At a low oxygen tension, HbS molecules tend to stick together and cause the red blood cells to sickle.

What Factor Affects the Red Cell's Tendency to Sickle in Sickle