What hematologic condition is associated with the appearance of Heinz bodies?

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Heinz bodies are denatured aggregates of hemoglobin that form in red blood cells. These aggregates are removed by the spleen, leading to hemolysis. Glucose 6-phosphate dehydrogenase (G6PD) deficiency is an X-linked genetic condition that leads to the formation of Heinz bodies. The deficiency causes a defect in the ability of red blood cells to regenerate reduced glutathione, which normally protects the cell from oxidative damage. The resulting accumulation of reactive oxygen species leads to the formation of Heinz bodies in red blood cells. Sickle cell anemia is a condition where the red blood cells assume a sickle shape leading to hemolysis. Liver disease and aplastic anemia do not have an association with Heinz bodies.

What Hematologic Condition Is Associated with the Appearance of Heinz