Vitamin B₁₂ deficiency can result in a macrocytic, megaloblastic anemia. This is because

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Vitamin B₁₂ is necessary for the production of DNA in rapidly dividing cells such as red blood cell precursors. In the absence of vitamin B₁₂, these precursors cannot divide properly and become large, immature cells known as megaloblasts. Folate is also necessary for DNA synthesis, and a deficiency in vitamin B₁₂ can lead to a secondary folate deficiency due to impaired absorption and utilization of folate. This can further exacerbate the inefficient production of red blood cells, leading to macrocytic anemia.

Vitamin B12 Deficiency Can Result in a Macrocytic, Megaloblastic Anemia

Vitamin B₁₂ Deficiency Can Result in a Macrocytic, Megaloblastic Anemia