A 26-year-old day laborer with a long history of anemia has a several-month history of dyspnea, fever, and pulmonary pain.Additionally, he complains of tightness in the chest and upper abdominal region.His hematology values are as follows:
WBC 15.9 $\times$ 10⁹/L
RBC 2.9 $\times$ 10¹²/L
Hgb 9.5 g/dL
Hct 30%
MCV 103 fL
MCH 31 pg
MCHC 32%
NRBC 15/100 WBC
Platelets 275 $\times$ 10⁹/L
Reticulocytes 16.8%
The hemoglobin electrophoresis results are as follows:
Hgb A = 3%
Hgb A₂ = 2%
Hgb S = 85%
Hgb F = 10%
The most likely diagnosis is:

Question

A 26-year-old day laborer with a long history of anemia has a several-month history of dyspnea, fever, and pulmonary pain.Additionally, he complains of tightness in the chest and upper abdominal region.His hematology values are as follows:
WBC 15.9

\times

10⁹/L
RBC 2.9

\times

10¹²/L
Hgb 9.5 g/dL
Hct 30%
MCV 103 fL
MCH 31 pg
MCHC 32%
NRBC 15/100 WBC
Platelets 275

\times

10⁹/L
Reticulocytes 16.8%
The hemoglobin electrophoresis results are as follows:
Hgb A = 3%
Hgb A₂ = 2%
Hgb S = 85%
Hgb F = 10%
The most likely diagnosis is:

Quizplus · Accepted Answer

The patient's hematology values are consistent with sickle cell disease, as he has a low hemoglobin level, high reticulocyte count, and a significant number of NRBCs. Additionally, the patient's hemoglobin electrophoresis results show a predominance of Hgb S, which is diagnostic of sickle cell disease. Beta thalassemia minor and sickle thalassemia would have different hemoglobin electrophoresis patterns. Sickle cell trait typically does not cause significant symptoms or laboratory abnormalities.

A 26-Year-Old Day Laborer with a Long History of Anemia ×\times×

A 26-Year-Old Day Laborer with a Long History of Anemia $\times$