If a Hydrophilic Amino Acid on the Surface of an Enzyme

If a hydrophilic amino acid on the surface of an enzyme were changed to a hydrophobic amino acid, which result would be possible?

A) The activity of the enzyme would remain unchanged.
B) The folding pattern of the enzyme's polypeptide chain would change.
C) The function of the enzyme could be expanded to allow it to bind many new substrates.
D) The tertiary structure would be stabilized by new hydrophobic interactions.
E) The protein's ability to form peptide bonds could be affected.