Which Statement Provides Evidence Supporting the Claim That Glucose Has

Which statement provides evidence supporting the claim that glucose has a specific binding interaction with a protein?

A) Incubation of the protein with glucose results in a change in protein shape that does not occur when the protein is incubated with another hexose sugar such as galactose.
B) A mixture of protein and glucose is separated when passed through a chromatography column.
C) The protein primary structure is analyzed and found to contain many hydrophilic amino acid residues that can form hydrogen bonds with glucose.
D) When a mixture of glucose and protein is placed inside a bag composed of a semipermeable membrane, glucose diffuses out while protein remains inside the bag.
E) The protein is found to be localized in a region of the cell where glucose is also present.