Nitric oxide (NO) participates in a signal transduction pathway that promotes relaxation of smooth muscle cells lining blood vessels and so increases blood flow.Nitric oxide accomplishes this by A) binding to receptors on the muscle cells. B) causing an increase in intracellular Ca²⁺. C) activating acetylcholine receptors. D) activating phosphodiesterase in the muscle cells. E) diffusing into the muscle cell and increasing cGMP.

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Quizplus · Accepted Answer

Nitric oxide diffuses into the muscle cell and increases cGMP, which leads to relaxation of the smooth muscle cells and increased blood flow.

Nitric Oxide (NO) Participates in a Signal Transduction Pathway That