Inborn errors of metabolism are more frequently encountered in highly consanguineous populations.To identify all mutations in the known genes responsible for a group of metabolic disorders that were common in such a population, researchers first established a pedigree of afflicted families, _______ the genes involved, then sequenced the products.

Question

Quizplus · Accepted Answer

Linkage analysis is a method used to determine the location of genes on a chromosome and their relative distance from each other. It can be used to identify the genes responsible for a specific trait or disease by analyzing the inheritance of genetic markers in families. In this scenario, the researchers would have used linkage analysis to identify the genes involved in the metabolic disorders before sequencing the products.

Answer: E
 PCR (polymerase chain reaction) is a technique used to amplify small amounts of DNA. It is commonly used in genetic research to amplify specific regions of DNA for sequencing or analysis. In this scenario, the researchers would have used PCR to amplify the products of the identified genes before sequencing them.

Inborn Errors of Metabolism Are More Frequently Encountered in Highly